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Table 2 List of previous and current studies conducted by the ER-RCBP

From: Building health research capacity in Africa: the Einstein-Rwanda research and capacity building program

ER-RCBP major studies’ recruitment, retention, and relevant activities and skills

Study

Years

Recruitment period

N

Follow-up period

Annual retention

Relevant activities and skills

Cervical cancer screening studies

RWISA

2005–2010

6 months

970

Q6m for 5 years

93%

Cytology, HPV testing, colpo, LEEP, biorepository

HPV demonstration project with CareHPV study (CxCa see and Treat, clinic- and community-based)

2009–2010

1 year

3100

Not applicable

NA

HPV, VIA, Cryotherapy, biorepository, CHW

Optimal methods for CxCa prevention among WWH

2015–2020

2 years

5061

2 years f/u of screen + WWH

89–91%

Xpert HPV, E6/7, p16, Ki67, image capture for AVE, colposcopy, thermal ablation, LEEP, biorepository, CHW

Anal high-risk human papillomavirus (hrHPV) and ASIL in Rwandan WWH with cervical HPV (pilot)

2019

1 month

50

NA

NA

Anal pap, HRA, anal/cervical HPV by Ampfire, biorepository

Other studies in people living with HIV

Prevalence and incidence of HPV, HIV, and anal disease in Rwandan MSM

2016–now

1 year

350

Q6m × 8

91%

ACASI, anal, penile specimens, HRA, Ampfire, biorepository, anal cytology

CA-IeDEA Sentinel Research Network

2020–now

9 months

600

6 months, 12 months, 24 months

99%

POC testing, fibroscan, ACASI, REDCap, biorepository

Reducing time to spaced-out appointments for newly diagnosed people living with HIV (pilot)

2020–2022

6 months

90

6 months, 12 months

97%

Clinical trial (pilot), REDCap

Cancer Registration

2010–now

Ongoing

19,906

NA

NA

Senior cancer registrars/trainer, transferred to RBC 2018; registry match with HIV; access to data

CA-IeDEA

2011–now

Ongoing

35,000

Ongoing

94%

Secondary data extracted from EMR

  1. ASIL Anal squamous intraepithelial lesions, ACASI Audio computer-assisted self-interview, AVE Automated visual evaluation, CA-IeDEA Central Africa International epidemiology Databases to Evaluate AIDS, CxCa Cervical cancer, colpo, colposcopy, ER-RCBP Einstein-Rwanda Research and Capacity Building Program, EMR Electronic Medical Record (OpenMRS), E6/E7, E6 and E7 HPV oncoproteins, HRA high-resolution anoscopy, MSM Men who have sex with men, NA Not applicable, POC Point of care, p16, p16 expression marker, Q6m, every 6 months, REDCap Research Electronic Data Capture, RBC Rwanda Biomedical Center (Ministry of Health), RWISA Rwanda Women’s Interassociation and Assessment, VIA Visual inspection with acetic acid, WWH Women living with HIV