Table 2 Mutations and their frequency among the DENV genomes, from this study, and Nepalese genomes from the GISAID database (N = 214), separated based on their region of occurrence

Structural

(viral particle region)

E_D192B

DENV1

1

1

E_L56J

DENV3

1

1

Nonstructural (viral replication complex)

NS4A_2K_L17M

DENV3

16

20

NS4A_2K_T20I

DENV3

16

20

NS2A_F159J

DENV1

1

1

NS2A_G130R

DENV2

1

1

NS2A_L211J

DENV2

1

1

NS2A_R55S

DENV2

1

1

NS2B_I97T

DENV2

1

1

NS2B_T52A

DENV3

2

2

NS3_A373S

DENV3

1

1

NS3_C375L

DENV3

1

1

NS3_D371stop

DENV3

1

1

NS3_E181D

DENV3

1

1

NS3_E93stop

DENV3

1

1

NS3_F362V

DENV3

1

1

NS3_G369R

DENV3

1

1

NS3_G380R

DENV3

1

1

NS3_I366H

DENV3

1

1

NS3_I372H

DENV3

1

1

NS3_K367Q

DENV3

1

1

NS3_K381E

DENV3

1

1

NS3_N370K

DENV3

1

1

NS3_N374K

DENV3

1

1

NS3_N379E

DENV3

1

1

NS3_R377A

DENV3

1

1

NS3_S365Q

DENV3

1

1

NS3_T532V

DENV2

1

1

NS3_V363C

DENV3

1

1

NS3_W361V

DENV3

1

1

NS5_I162G

DENV3

1

1

NS5_R248K

DENV3

1

1