Table 2 Indirect comparison of sensitivity of different self-swabbing approaches (mid-turbinate vs. nose and throat)
|  | SS-MT-LFD1a [34] Mid-turbinate (N = 1102) | SS-NT-LFD2c [34] Nose and throat (N = 635) | Difference (95% CI); p valued | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | TP | TN | FP | FN | Sensitivity, % (95% CI)b | N | TP | TN | FP | FN | Sensitivity, % (95% CI)b | ||
Overall | 1102 | 237 | 775 | 2 | 88 | 72.9 (67.7–77.7) | 631 | 415 | 0 | 0 | 216 | 65.8 (61.9–69.5) | 7.2 (0.8–13.5); p = 0.03 |
Viral concentration | |||||||||||||
 < 10 K | 48 | 9 | 0 | 0 | 39 | 18.8 (9.0–32.6) | 66 | 13 | 0 | 0 | 53 | 19.7 (10.9–31.3) |  − 1.0 (− 16.5–14.6); p = 1.00 |
 10 K–1 M | 110 | 70 | 0 | 0 | 40 | 63.6 (53.9–72.6) | 216 | 118 | 0 | 0 | 98 | 54.6 (47.7–61.4) | 9.0 (− 2.9–20.9) p = 0.15 |
> 1 M | 154 | 151 | 0 | 0 | 3 | 98.1 (94.4–99.6) | 349 | 284 | 0 | 0 | 65 | 81.4 (76.9–85.3) | 16.7 (11.6–21.8) p < 0.005 |